Toremifene Dosage Guide + Max Dose, Adjustments

However, the Nordic Study showed a longer time to progression for tamoxifen (see table). The pharmacokinetics of toremifene in patients of different races has not been studied. Fourteen percent of patients in the North American Study were non-Caucasian. No significant race-related differences in FARESTON effectiveness or safety were noted.

Possible Side Effects of Toremifene

Elimination half-life prolonged and Vd increased (457 vs 627 L) observed in elderly women. Cataracts, dry eyes, abnormal visual fields, corneal keratopathy, glaucoma, abnormal vision/diplopia, and corneal opacity (corneal verticulata) reported. Blurred vision reported following therapy with higher than recommended dosages (i.e., 200 or 240 mg daily). Obtain liver function tests periodically during therapy. Monitor serum calcium concentrations periodically during therapy. Premenopausal women using FARESTON should use nonhormonal contraception during treatment and should be apprised of the potential hazard to the fetus should pregnancy occur [see WARNINGS AND PRECAUTIONS].

• Take all your medicines exactly as they have been explained to you.
• Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
• The incidence reflects the toxicities that were considered by the investigator to be drug related or possibly drug related.
• Toremifene inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors.

Missed Dose

You may report side effects to your national health agency. This drug may interact with other drugs or health problems. Based on the mechanism of action and data from animal reproduction studies, in utero exposure to toremifene may cause fetal harm. The mean elimination half-life was increased by less than 2-fold in patients with cirrhosis or fibrosis.

Toremifene decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue. This may stop the development of tumors that need estrogen to grow. In rodent models of fetal reproductive tract development, toremifene produced inhibition of uterine development in female pups similar to effects seen with diethylstilbestrol (DES) and tamoxifen. Neonatal rodent studies have not been conducted to assess the potential for toremifene to cause other DES-like effects in offspring (i.e., vaginal adenosis). Vaginal adenosis in animals occurred following treatment with other drugs of this class and has been observed in women exposed to diethylstilbestrol in utero. As with other antiestrogens, hypercalcemia and tumor flare have been reported in some breast cancer patients with bone metastases during the first weeks of treatment with FARESTON.

Use effective birth control if you are not past menopause. No adjustment listed in the manufacturer product information; however, hepatic impairment increases the half-life of this drug. You will have blood tests to check how well your liver is working. You may feel low or depressed, or have mood swings, during this treatment. Talking to family and friends about how you feel might help. If mood changes last for more than a few weeks, tell your doctor, nurse or pharmacist.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Follow all directions on your prescription label and read all medication guides or instruction sheets. You should not use toremifene if you have a history of long QT syndrome, or low levels of potassium or magnesium in your blood.

where to buy steroids is used in postmenopausal women to treat breast cancer. It is usually used to treat cancer that needs estrogen, a hormone, in order to grow (estrogen-receptor positive). Toremifene is a nonsteroidal antiestrogen that blocks the effects of estrogen in the breast tissue, thereby slowing or stopping the growth of cancer.

This medicine blocks the effects of the estrogen hormone. As a result, the amount of estrogen that the tumor is exposed to is reduced, which will limit the growth of the tumor. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.